Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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Several herbs and plants with diversified pharmacological properties have been shown to have potential to prevent human cancers as they possess antitumor substances which have the potential to cure cancer without causing toxicity. The present study was undertaken to evaluate the anticancer activity of two medicinal plant s Andrographis paniculata and Silybum marianum aerial part and their combinational effects against five human cancer cell lines i.

These medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer activities. PDF Kb Abstract Plant-derived compounds act andrograhis a prevention within the development of many anti-cancer agents. To the og of our reference, the only conducted research related to salt stress in A.

Phyto chemical analysis of hydroalcoholic extract of A. The broad-sense heritability was calculated for all studied characteristics.

As a matter of fact, a andrgoraphis of this enhancement could be due to an obvious reduction of the plant biomass. The trend of proline and the three main phytochemicals in tolerant accession were linear and positive, while in sensitive accession they were nonlinear. Anticancer activity of combinational effects of A.


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The combination of both the plants 1: The process of programmed cell death is called apoptosis. The correlative aspects of phytochemical production as well as the accumulation of proline in salt-tolerant a and salt-sensitive b A.

These compounds are produced mainly from aerial organs of the plant, especially leaves. Phenols, polyphenols, flavonoids and their derivatives are ubiquitous in plants and have been found associated with the inhibition of atherosclerosis and cancer Cirla and Mann, After four weeks, a significant decrease in growth driven by salinity was apparent in all accessions.

Five human cancer cell lines i. To be clearer, it seems that the accessions with high contents of the anticancer phytochemicals under normal condition would deal more successfully with salinity, as well. Phytochemical study showed the presence of flavonoids, tannins, carbohydrate, cardiac glycosides, terpenes and steroids in both the plant extracts.

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Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

Vertical bars represent standard error of mean for three samples. Generally, plants produce secondary metabolites in nature as defense mechanisms under different environmental stresses [ 27 ]. Similarly, alkaloids like schischkinnin and montamine have been isolated from the seeds of Centaurea schischkinii and Centaurea montana which showed anticancer property Yang and Wang, However, to prove their efficacy for clinical utilization more scientific data are needed.

Effects of salinity levels on TDW, proline and three main phytochemicals in tolerant and sensitive accession of A. Culturing of cell line: At high salinity level, the tolerant plants were able to tolerate the salinity stress due to the accumulation of osmoregulation and compatible solutes such as proline and soluble flavonoids, while the sensitive accessions were unable to withstand the salinity stress due to the accumulation of sodium ion.

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The germinated seeds at two initial leaf stages were transferred into the Jiffy media.

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Among these phytochemicals, three diterpene lactones consisting of andrographolide AGneoandrographolide NAGand deoxy,didehydroandrographolide DDAG possess the highest bioactivity in treating the hardly curable diseases [ 1718 ]. Cytotoxic effect of Plantago spp. Phyto chemical analysis was performed to detect various compounds such as tannins, flavonoids, alkaloids, steroids etc.

A pilot double blind study. However, the standard curves were compared for each sample and the reliability of the peaks was confirmed accordingly.

Abstract Andrographis paniculata and Silybum marianum are well known medicinal plants. View at Google Scholar K.

After 30 days of culturing almost in 70 days oldthe plants were placed in different salinity levels. Fundamentally, it can be concluded that if the production of anticancer phytochemicals of A.

Journal of Pharmacology and Toxicology, 8: The antioxidant phytochemicals protect the cells from oxidative damage. Components of variance and broad-sense heritability activihy studied characters in A. View at Google Scholar H.